Osps suppress the immune system

Vertaling https://www.truthcures.org/immunosuppression

OspA (Pam3Cys) causes immunosuppression – OspA (Pam3Cys) veroorzaakt immunosuppressie

Veel onderzoeksgroepen hebben bevestigd dat OspA het immuunsysteem aantast, immunosuppressie veroorzaakt en apoptose remt, het natuurlijke proces van geprogrammeerde celdood dat infecties zou moeten beperken. Een groep Lyme-experts, waaronder Allen Steere, Gary Wormser, Paul Mead, John Branda, Franc Strle en Linden Hu, publiceerden in december 2016:

“This finding suggests that there is redundancy in the ability of the innate immune system to recognize B. burgdorferi and/or that these components can activate pathways that produce anti-inflammatory cytokines……the anti-inflammatory [immunosuppressive] effects might be the more important function of TLR signaling.”

Gary Wormser van het New York Medical College, in 2000:

“The modulation of human lymphocyte proliferative responses was demonstrated with a recombinant outer surface protein A (OspA) vaccine preparation for the prevention of Borrelia burgdorferi infection. After exposure to either the unaltered vaccine preparation or OspA prepared in saline, normal lymphocyte responses to the mitogens concanavalin A, phytohemagglutinin-M or pokeweed mitogen, or the antigen BCG were consistently reduced. Whole cell extracts of B. burgdorferi also modulated immune responses but required a much greater quantity of protein than needed for the OspA preparation. The magnitude of modulation was directly dependent on the quantity of OspA. OspA interferes with the response of lymphocytes to proliferative stimuli including a blocking of cell cycle phase progression. Future studies designed to delete the particular region or component of the OspA molecule responsible for this effect may lead to improved vaccine preparations.”

Mario Philipp van de Tulane University publiceerde in 1998:

“These results demonstrate that B. burgdorferi can stimulate the production of an antiinflammatory, immunosuppressive cytokine in naive cells and suggest that IL-10 may play a role both in avoidance by the spirochete of deleterious immune responses and in limiting the inflammation that the spirochete is able to induce.”

En al in 1988 meldde Raymond Dattwyler van de State University van New York in Stony Brook ‘een duidelijke remming’ van de activiteit van natural killer-cellen bij blootstelling aan Borrelia en zijn triacyllipoproteïnen.

“…when lymphocytes are cultured in the presence of growing Bb there is a marked inhibition ( p < .0005 ) of NK activity on days 3, 5, and 7 when compared to lymphocytes cultured in BSKII media in the absence of spirochetes…The inhibition is directly attributable to the organism or its supernatants (data not shown).”

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